HIV, the virus that can lead to AIDS, is spread via contact with infected bodily fluids. As such, people who inject drugs (PWID) can contract HIV through contaminated syringes. Syringe service programs (SSPs) dispose of used needles and distribute sterile syringes with the goal of reducing disease spread amongst PWID. This Science and Technology Note discusses HIV and SSPs in West Virginia and offers policy options to limit HIV outbreaks by expanding West Virginians’ access to SSPs.